Troubles with XP-Pen on Harmony Advanced

I only now noticed I had posted a request for help in the wrong place, I put it in Animate rather than Harmony support, Woops.
I have no idea what process I’d need to go through to get it moved so a bit of a redirect if you can help at all.

https://forums.toonboom.com/animate/support-and-troubleshooting/problems-xp-pen-22-hd-tablet

tl;dr
Was having various problems with my XP-Pen 22hd tablet on my Win10 64 bit multi-monitor setup.
I diagnosed most of it but as of now can only run Harmony Advanced with one of three ways; one screen with pressure and alignment, multi screen with pressure or multi-screen with alignment depending on how “run as admin” is toggled. Entire process in the above link.

Been reading and watching other people solutions and this is where I stand now. Any different ideas?