When you lose pressure sensitivity, try deleting all tablet drivers except for the one powering your current tablet.
Next, delete all tablet preference files on the system (tablet.dat, tablet.pref, wacom.dat, wacom.pref).
Redo all your tablet preferences using the tablet utility.
Avoid changing screen resolution because this can cause the preferences to become unset and you would
need to repeat the last two steps when this happens. It may help to rename the folder
C:\Documents and Settings\Application Data\Toon Boom Animation\Toon Boom Animate Pro 2\full-900-pref
and to redefine your Animate Pro 2 preferences as a last step.