Can i work with mouse???
There is nothing preventing you from using a mouse however there are enhancements that will not be available to you like pressure sensitivity that produces varied line weight.
Drawing with a mouse is difficult for most people and it is more natural to draw with a tablet and pen.
One way to get the most out of the software without a mouse is to draw your art on paper, scan it and convert it to vector art. You can do some manipulation of vector art using a mouse.
You could also create a world made up of geometric forms. Use basic squares, rectangles, lines, ovals, circles, rather than more organic forms.
The Polyline tool is useful with a mouse. It is more like laying down a line whereas drawing is making a stroke to produce a line. The added control would benefit someone using only a mouse.