Adding textures to a color

Kind of wanted to ask if there’s a way to pull off a sort of detailed color palette in Toon Boom Harmony.

To put it in perspective, I wanted to see if one could pull off a style that seems reminiscent of Courage the Cowardly Dog. (And maybe Samurai Jack, but I don’t know about the latter.) Basically the environments would be drawn by hand drawn with the colors and textures having a sort of realistic texture to it. (Although edited through the composition phase.) Bare in mind that I have Harmony Advanced, so I don’t think I have the node setup tools. ;_;

Examples
https://wallpaperaccess.com/full/281209.jpg
https://i.pinimg.com/originals/f5/3c/92/f53c92422d46f1b632a231e709d93f8c.jpg

I know there is a way to do so thanks to masking and adding multiple layers. But I wanted to see if one could make a more simplified way.