Blender has been developing some interesting 2D features lately with the grease pencil and there is one tool id love to see in toonboom harmony.
Basically, when you draw a line and then go to sculpt mode, there is a tool called, the push tool.
This tool helps move smoothly around the lines to reshape the drawing quick easy.
This especially is useful for making in-between drawing without redrawing the whole thing to create a smooth animation for frame by frame animations.
Here is a quick example where around halve of it was just pushing the lines, speeding the process Dropbox - mlpht12fps.gif - Simplify your life